If it is sand particles, then they do not raise up once you start driving the car. Also, it would depend on the type of circulation of air that you have chosen the moment you have started your car. Though you are ready to spend money on the petrol for running the air condition in the car, still why you choose a different type of air circulation would all depend on your understanding of the path or journey that you would be doing until you reach the destiny.
Though you know majority of the route would be empty with barren lands on either side of the road thus filling the atmosphere around you with fresh air, still in between you could come across the cities that are polluted with the construction. Since these cities or villages might appear suddenly you could not get enough time to change the settings in your car. This would result in letting the polluted air enter the car. So, under such circumstances there are chances that you are doing risk with your own life if you have respiratory issues and hence it is mandatory to breathe in fresh air all the time.
So, it is the best time for you to think of buying the best car vacuum cleaner than to get sick by breathing in the polluted air. When you think you are done half the way to your destination it is obvious that you would stop to have a nap or else to have some food so that you are energetic until you reach the destination. This is when you could use to clean the car as well just in couple minutes so that the rest of the half journey also would be as smooth and as comfortable as is the first half of the journey.